• About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News
Saturday, July 12, 2025
  • Login
Metro City News
  • Home
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
  • Auto
  • Finance/Money
  • Sports
  • Others
    • Agriculture
    • Science
    • Astrology
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
  • Home
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
  • Auto
  • Finance/Money
  • Sports
  • Others
    • Agriculture
    • Science
    • Astrology
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
Metro City News
No Result
View All Result
Home Lifestyle Health & Fitness

Opioid addiction treating drug may be repurposed for type 2 diabetes

Metro City News Desk by Metro City News Desk
November 3, 2020
in Health & Fitness
Share on FacebookShare on Twitter

New Delhi: India is the diabetic capital of the world as every sixth person with diabetes in the world is an Indian. Insulin resistance has been a big challenge for researchers who seek to understand and treat it. Researchers from the Indian Institute of Technology, Mandi (IIT Mandi) have unraveled the mechanism by which insulin overload in the body causes insulin resistance that is associated with diabetes. They have found the drug that is used in treating opioid addiction can potentially reverse this phenomenon.

“We’ve known that one of the causes of insulin resistance is inflammation”, says Dr Prosenjit Mondal, Associate Professor, School of Basic Sciences, IIT Mandi, “We wanted to find out if and how hyperinsulinemia (excess insulin traversing the bloodstream) invokes inflammation in the body, which would provide the link between the two conditions,” he told.

RelatedPosts

VRA Health Bridges Healthcare Gaps: From COVID Crisis to Global Telemedicine Success

VRA Health Bridges Healthcare Gaps: From COVID Crisis to Global Telemedicine Success

July 7, 2025
ClinicSpots Simplifies Online Doctor Consultation in India, Connecting Patients to Trusted Healthcare Experts Across Specialties

ClinicSpots Simplifies Online Doctor Consultation in India, Connecting Patients to Trusted Healthcare Experts Across Specialties

July 1, 2025

The relationship between insulin resistance and hyperinsulinemia is cyclic – each increases the occurrence of the other. While it is obvious how insulin resistance leads to hyperinsulinemia – when cells cannot use the insulin, it just remains in the blood – the converse of how hyperinsulinemia increases insulin resistance has hitherto remained unclear.

The Indian Institute of Technology, Mandi (IIT Mandi) have unravelled the mechanism by which insulin overload in the body causes insulin resistance that is associated with diabetes.

The researchers identified a critical protein molecule – SIRT1 which is repressed in hyperinsulinemia. They discovered that a decrease in SIRT1 activates another protein called NFkB, which instigates inflammation, thus providing the link between hyperinsulinemia and systemic inflammation. The team has also discovered a solution to this problem. The researchers found that low-dose naltrexone (LDN), a drug commonly administered for opiate addiction, can activate SIRT1, thereby reducing inflammation and increasing insulin sensitivity of cells.

The significance of this discovery is enormous. “Naltrexone at low doses could potentially restore some of the diabetes-associated events in cellular and animal models”, observed Dr Mondal, who is confident that this is a viable path to follow for Type-2 diabetes management. Naltrexone is already an FDA-approved drug that is used for the treatment of opioid addiction and can easily be repurposed for inflammation reduction and diabetes control. The research team intends to study this thread further, to understand the mechanistic aspects of LDN’s effects on hyperinsulinemia-induced inflammation and resulting insulin resistance.

The study has been carried out with grant support from the Science and Engineering Research Board (SERB). The research team comprised Dr. Prosenjit Mondal, Abhinav Choubey, Khyati Girdhar from IIT Mandi, Dr. Debabrata Ghosh, Aditya K. Kar, and Shaivya Kushwaha from CSIR- Indian Institute of Toxicology Research, Lucknow and Dr. Manoj Kumar Yadav from SRM University, Delhi-NCR, Sonipat, Haryana. The research findings have recently been published in the Journal of Biological Chemistry. (India Science Wire)

Tags: diabetesIIT MandiIndian Institute of Technology
ShareTweetShareSendSharePinSend
Previous Post

Surat IntStu Aspirations celebrates Halloween in full fledge

Next Post

With a mission in fitness and health, Chakra helps to provide Indians with a unique spinning experience

Metro City News Desk

Metro City News Desk

Related Posts

VRA Health Bridges Healthcare Gaps: From COVID Crisis to Global Telemedicine Success
Health & Fitness

VRA Health Bridges Healthcare Gaps: From COVID Crisis to Global Telemedicine Success

by Metro City News Desk
July 7, 2025
ClinicSpots Simplifies Online Doctor Consultation in India, Connecting Patients to Trusted Healthcare Experts Across Specialties
Health & Fitness

ClinicSpots Simplifies Online Doctor Consultation in India, Connecting Patients to Trusted Healthcare Experts Across Specialties

by Metro City News Desk
July 1, 2025
As COVID-19 Cases Resurface, Pravek Kalp Promotes Ayurvedic Immunity and Heart Health with Ashwagandha and Arjuna Capsules
Health & Fitness

As COVID-19 Cases Resurface, Pravek Kalp Promotes Ayurvedic Immunity and Heart Health with Ashwagandha and Arjuna Capsules

by Metro City News Desk
May 27, 2025
Aveya IVF & Fertility Center: Pioneering Accessible Parenthood with Fertility Solutions
Health & Fitness

Aveya IVF & Fertility Center: Pioneering Accessible Parenthood with Fertility Solutions

by Metro City News Desk
May 14, 2025
Patna Welcomes World-Class Mental Health Care Through Dr. Vivek Pratap Singh’s Unique Neuro & Child Psychiatry Services
Health & Fitness

Patna Welcomes World-Class Mental Health Care Through Dr. Vivek Pratap Singh’s Unique Neuro & Child Psychiatry Services

by Metro City News Desk
May 12, 2025
Rooted in Breath: Sagar Uddhav Shende’s Path to Pancha Koshas
Health & Fitness

Rooted in Breath: Sagar Uddhav Shende’s Path to Pancha Koshas

by Metro City News Desk
April 29, 2025
Next Post

With a mission in fitness and health, Chakra helps to provide Indians with a unique spinning experience

Tyre, auto, transport business’ help IPL 2020 Season ride to success

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

CSIR scientists develop sensor to monitor health status on the go

March 17, 2021
Renowned fashion designer and celebrity stylist Seema Kalavadia launches khadi collection for festive season

Renowned fashion designer and celebrity stylist Seema Kalavadia launches khadi collection for festive season

November 2, 2021

A new automated system to detect colorectal cancer

March 5, 2021

KCS Partners with Leading Conversational AI-based Multilingual Bot Provider BotSupply to Create the CX for the Future

September 7, 2020
A new technique to help avoid sudden power shutdowns

A new technique to help avoid sudden power shutdowns

September 2, 2021
CELEBRATING 75 – The 18th Asia–Africa Business and Social Forum: Awards & Business Summit 2022 and Greatest Brands and Leaders 2021-22 – Asia–Americas–Africa

CELEBRATING 75 – The 18th Asia–Africa Business and Social Forum: Awards & Business Summit 2022 and Greatest Brands and Leaders 2021-22 – Asia–Americas–Africa

August 30, 2022

La Mira Fashion – Stylish yet comfy !

April 12, 2021

CSIR-SERC licenses makeshift hospital’s technology to L&T

November 5, 2020

Nirula’s expands its menu & network for a new generation of foodies

April 27, 2023

India’s Largest Dental Chain, Clove Dental Organizes its 38th Leadership Conclave on its 14th Anniversary

March 28, 2025

Child Help Foundation (CHF) and Filaantro Volunteered to Raise funds for Assam Flood Relief

August 3, 2022

Lexicon MILE Empowers Students with Industry-Ready Skills Through Additional Certifications

May 21, 2024

Moradabad’s philanthropist Arvind Goel explains the big picture of population explosion

July 13, 2022

Jahangir Tutorials: Bridging the Language Gap for South Indian Commerce Aspirants

May 13, 2025

Delhi gets its first world-class Sound Centre for Hearing Care

August 6, 2021

Author Soma Bose’s Debut Book Released in Mumbai by Amole Gupte and Shrabani Deodhar

October 16, 2023

Categories

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion & Beauty
  • Finance/Money
  • Food
  • Health & Fitness
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • Uncategorized
  • World

Recent News

Siddhartha Institute of Engineering & Technology, Telangana, Siddhartha College

How Siddhartha is Giving its Core Engineering Students a Serious Advantage in the AI Age

July 11, 2025
Shaligram Infotech, A Trusted Microsoft Partner In India, Marks 10 Years With Rebranding And Expanded Global Focus

Shaligram Infotech, A Trusted Microsoft Partner In India, Marks 10 Years With Rebranding And Expanded Global Focus

July 9, 2025
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News

© 2022 Metro City News

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

© 2022 Metro City News

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In